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May 27, 2017

Haviv Levi, Karl Schoknecht, Ofer Prager, Yoash Chassidim, Itai Weissberg, Yonatan Serlin, Alon Friedman, Stimulation of the Sphenopalatine Ganglion Induces Reperfusion and Blood-Brain Barrier Protection in the Photothrombotic Stroke Model. PLoS ONE, June 2012 | Volume 7 | Issue 6 | e39636

A. Bar-Shir, N. Shemesh, R. Nossin-Manor,Y. Cohen., Late Stimulation of the Sphenopalatine-Ganglion in Ischemic Rats: Improvement in N-Acetyl-Aspartate Levels and Diffusion Weighted Imaging Characteristics as Seen by MR, Journal of Magnetic Resonance Imaging 31:1355-1363 (2010) (pdf)

D. Khurana, S. Kaul, and N. M. Bornstein, for the ImpACT-1 study group, Implant for augmentation of cerebral blood flow trial 1:a pilot study evaluating the safety and effectiveness of the Ischaemic Stroke System for treatment of acute ischaemic stroke: Clinical Protocol, International Journal of Stroke Dec 2009(4):480-485 (pdf)

Bar-Shir et al., Long Therapeutic Window in Sphenopalatine Ganglion Stimulated Ischemic Rats: An MRI and MRS Study, Accepted as a poster at the International Stroke Conference, February 2009, San-Diego, CA

Fisher et al., Implant for Perfusion Augmentation Clinical Trial -1 (ImPACT-1).  A Safety and Effectiveness evaluation of the Ischemic Stroke System (ISS*) in the treatment of Acute Ischemic Stroke - Pilot study report. Accepted as a poster at the International Stroke Conference, February 2009, San-Diego, CA

Kaul et al., Implant for Augmentation CBF Clinical Trial-1 (ImPACT-1). A Safety and Efficacy evaluation of the Ischemic Stroke System (ISS*) in the treatment of Acute Ischemic Stroke - An interim analysis, Poster at the World Stroke Congress, September 2008, Vienna, Austria

Borenstein et al., Implant for Augmentation CBF Clinical Trial-1 (ImPACT-1). Safety and Efficacy of the Ischemic Stroke System (ISS*) in the treatment of Acute Ischemic Stroke - An interim analysis, Presentation at the European Stroke Conference, May 2008, Nice, France

Solberg et al., Effectiveness of Sphenopalatine Ganglion Stimulation Therapy in Focal Ischemic Stroke Models: a 24-hour Post-Stroke Window of Treatment, Poster at the International Stroke Conference, February 2008, New Orleans, LA

Khurana et al., The Ischemic Stroke System (ISS)*: an easy-to-use neuro-stimulator for the treatment of acute ischemic stroke, Poster at the International Stroke Conference, February 2008, New Orleans, LA

Kaul et. al., Implant For Augmentation Of Cerebral Blood Flow Clinical Trial (ImPACT-1)  interim analysis, A Multicentric international pilot clinical study. Presentation at the International Stroke Conference, February 2008, New Orleans, LA

Yarnitsky et al., Increased BBB permeability by parasympathetic sphenopalatine ganglion stimulation in dogs.   Brain Res. 2004 Aug 27;1018(2):236-40 (pdf)

Yarnitsky et al., Blood-brain barrier opened by stimulation of the parasympathetic sphenopalatine ganglion: a new method for macromolecule delivery to the brain. J Neurosurg. 2004 Aug;101(2):303-9 (pdf)

Yarnitsky et al., Reversal of cerebral vasospasm by sphenopalatine ganglion stimulation in a dog model of subarachnoid hemorrhage. Surg Neurol. 2005 Jul;64(1):5-11 (pdf)

Yarnitsky et al., Sphenopalatine ganglion (SPG) stimulation in acute stroke model: a novel method for neuroprotection. Poster in 2006 International Stroke Conference, Orlando, FL

July 16, 2014
ImpACT24 Interim Results
The Data Safety Monitoring Board (the "DSMB") for BrainsGate's study examined the interim results and deterimined the results support the continuation of the study > full story
January 1, 1970
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